Pathways & interactions
Doublesex- and mab-3-related transcription factor 1-like (IPR022114)
Short name: DMRT1-like
Overlapping homologous superfamilies
- DMRT/protein doublesex/protein male abnormal 3 (IPR026607)
- Doublesex- and mab-3-related transcription factor 1-like (IPR022114)
This family is found in eukaryotes, and is typically between 61 and 73 amino acids in length. They are suggested to be transcription factor proteins.
In Xenopus laevis, doublesex- and mab-3-related transcription factor 1a (dmrt1-a) is a transcription factor that plays a key role in male sex determination and differentiation by controlling testis development and germ cell proliferation. It acts both as a transcription repressor and activator [PMID: 17118014, PMID: 20573695]. However, the other family member in Xenopus laevis, doublesex- and mab-3-related transcription factor DM-W (dm-w), is a transcription factor that plays a key role in female sex determination and primary ovary development. It acts as a sex-determining protein by antagonizing the transcriptional activity of male-determination protein dmrt1-a, acting as a dominant-negative type protein [PMID: 18268317, PMID: 20573695].
- PF12374 (Dmrt1)