Microcephalin-like (IPR022047)

Short name: Microcephalin-like

Family relationships


Microcephalin is implicated in chromosome condensation and DNA damage induced cellular responses [PMID: 15199523, PMID: 15220350]. It may play a role in neurogenesis and regulation of the size of the cerebral cortex in animals. It is a protein, which if expressed homozygously, causes the organism to have the condition microcephaly - a drastically reduced brain mass and volume [PMID: 12046007]. Microcephalin is predicted to contain three BRCA1 C-terminal domains, the first of which is the probable microcephaly mutation site.

This entry includes non-mammalian uncharacterised proteins (from lower vertebrates and fungi) related to microcephalin.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.