Domain

Telomere-associated protein Rif1, N-terminal (IPR022031)

Short name: Rif1_N

Domain relationships

None.

Description

This domain is found in N-terminal of the telomere-associated protein,Rif1. In budding yeast, Rif1 is Recruited to telomeres by interaction with the C terminus of RAP1 is recruited to telomeres by interaction with the C terminus of RAP1 and negatively regulates telomere length by preventing telomere elongation or promoting degradation of the telomere ends [PMID: 1577274, PMID: 9087429]. In mammals, Rif1 is required for checkpoint mediated arrest of cell cycle progression in response to DNA damage during S-phase (the intra-S-phase checkpoint) [PMID: 15342490].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam