Domain

U1 small nuclear ribonucleoprotein of 70kDa N-terminal (IPR022023)

Short name: U1snRNP70_N

Domain relationships

None.

Description

This domain is about 90 amino acids in length and is found at the N terminus of U1 small nuclear ribonucleoprotein 70 kDa (U1-70K), which is part of the U1 snRNP (snRNP) complex. U1 snRNP recognises the 5' splice site within precursor messenger RNAs and initiate the assembly of the spliceosome for intron excision.

The N-terminal region of U1-70K extends over a distance of 180 A from its RNA binding domain, wraps around the core domain of U1 snRNP consisting of the seven Sm proteins and finally contacts U1-C, which is crucial for 5'-splice-site recognition [PMID: 19325628].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam