Nup358/RanBP2 E3 ligase domain (IPR022011)

Short name: IR1-M

Overlapping homologous superfamilies


Domain relationships



This domain family is found in eukaryotes, and is approximately 60 amino acids in length. The family is found in association with PF00638, PF00641, PF00160. There are two conserved sequence motifs: TFFC and EDF. Nup358/RanBP2 is a nucleoporin involved in ubiquitination of many different protein targets from various cellular pathways. It complexes with Ubc9, SUMO-1 and RanGAP1 to perform this function. This is the ligase domain which binds to Ubc9.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.