Domain

TSG101 and ALIX binding domain of CEP55 (IPR022008)

Short name: EABR

Overlapping homologous superfamilies

None.

Domain relationships

None.

Description

This domain family is found in eukaryotes, and is approximately 40 amino acids in length. This domain is the active domain of CEP55. CEP55 is a protein involved in cytokinesis, specifically in abscission of the plasma membrane at the midbody. To perform this function, CEP55 complexes with ESCRT-I (by a Proline rich sequence in its TSG101 domain) and ALIX. This is the domain on CEP55 which binds to both TSG101 and ALIX. It also acts as a hinge between the N and C termini. This domain is called EABR.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam