I-kappa-kinase-beta NEMO binding domain (IPR022007)

Short name: IKKbetaNEMObind

Overlapping homologous superfamilies


Domain relationships



This domain family is found in eukaryotes, and is approximately 40 amino acids in length. The family is found in association with PF00069. These proteins are involved in inflammatory reactions. They cause release of NF-kappa-B into the nucleus of inflammatory cells and upregulation of transcription of proinflammatory cytokines. They perform this function by phosphorylating I-kappa-B proteins which are targeted for degradation to release NF-kappa-B. This kinase (I-kappa-kinase-beta) is found in association with IKK-alpha and NEMO (NF-kappa-B essential modulator). This domain is the binding site of IKK-beta for NEMO.

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0008384 IkappaB kinase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.