Domain

Mediator complex, subunit Med12, catenin-binding (IPR021989)

Short name: Mediator_Med12_catenin-bd

Domain relationships

None.

Description

This domain is found in eukaryotes, and is typically between 325 and 354 amino acids in length. It is found in the C-terminal region of the mediator of RNA polymerase II transcription subunit 12. Both development and carcinogenesis are driven by signal transduction within the canonical Wnt/beta-catenin pathway through both programmed and unprogrammed changes in gene transcription. Beta-catenin physically and functionally targets this PQL (proline-, glutamine-, leucine-rich) region of the Med12 subunit of Mediator to activate transcription. The beta-catenin transactivation domain binds directly to isolated Med12 and intact Mediator both in vitro and in vivo, and Mediator is recruited to Wnt-responsive genes in a beta-catenin-dependent manner.

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0008013 beta-catenin binding

Cellular Component

GO:0016592 mediator complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam