Protein of unknown function DUF3583 (IPR021978)

Short name: DUF3583

Overlapping homologous superfamilies


Family relationships



This domain is found in eukaryotes, and is typically between 302 and 338 amino acids in length. It is found in association with IPR018957 and IPR000315. Most members are promyelocytic leukemia proteins, and this family lies towards the C terminus.

Proteins containing this domain include PML protein from mammals. PML (promyelocytic leukaemia) functions via its association with PML-nuclear bodies (PML-NBs) in a wide range of important cellular processes, including tumor suppression, transcriptional regulation, apoptosis, senescence, DNA damage response, and viral defense mechanisms [PMID: 15356634].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.