Rifampin ADP-ribosyltransferase (IPR021975)

Short name: Rifampin_Arr

Overlapping homologous superfamilies

Domain relationships



Arr enzymes catalyze ADP-ribosylation of rifamycins, thus rendering rifamycin antibiotics ineffective. The opportunistic pathogen Mycobacterium smegmatis possesses a chromosomally encoded rifampin ADP-ribosyltransferase (Arr-ms). An homologue of Arr, Arr-2, is present in several transposons and integrons found in Gram-negative pathogenic bacteria. The structure of Arr-ms reveals similarity to protein ADP-ribosyltransferases, despite a lack of amino acid sequence similarity [PMID: 18349144].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.