Domain

Small G protein signalling modulator 1/2, Rab-binding domain (IPR021935)

Short name: SGSM1/2_RBD

Overlapping homologous superfamilies

None.

Domain relationships

Description

This domain adopts a PH-like fold. It has been called the Rab-binding domain (RBD) [PMID: 25220469].

Small G-protein signalling modulator 1/2 (also known as RUTBC2/1) bind to Rab9A via their Pleckstrin homology (PH) domain [PMID: 22637480, PMID: 26620560]. RUTBC1 stimulates GTP hydrolysis by Rab32 and Rab33B [PMID: 26620560], while RUTBC2 appears to be a GAP for Rab36, Rab9A and associated proteins controling the recycling of mannose-6-phosphate receptors from late endosomes to the trans-Golgi [PMID: 25220469, PMID: 22637480, PMID: 17509819].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam