Domain

Sox C-terminal transactivation domain (IPR021934)

Short name: Sox_C_TAD

Domain relationships

None.

Description

The Sox family of high mobility group (HMG) box transcription factors that are homologous to the Y-chromosome encoded sex-determining factor SRY play important roles in embryonic development. Sox18, together with Sox7 and -17, constitutes the subgroup F within this family. Bioinformatic analysis of the C-termini of subgroup F Sox family members from different species including humans, mice, rat, chicken and Xenopus revealed three conserved blocks including highly conserved residues. They were termed proline, charged, and serine according to the predominance of the respective amino acids. The charged block comprises a strong transactivating domain [PMID: 17603017].

This entry covers the entire Sox C-terminal transactivating domain.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE profiles
Pfam