Large proline-rich protein BAG6 (IPR021925)

Short name: BAG6

Overlapping homologous superfamilies


Domain relationships



This domain is found in large proline-rich protein BAG6 protein. It has a conserved SDL sequence motif.

Human BAG6 is an ATP-independent molecular chaperone preventing the aggregation of misfolded and hydrophobic patches-containing proteins [PMID: 21636303]. It functions as part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, which maintains these client proteins in a soluble state and participates to their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation [PMID: 20516149, PMID: 21636303, PMID: 21743475, PMID: 28104892].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.