Domain

WASH1, WAHD domain (IPR021854)

Short name: WASH1_WAHD

Domain relationships

None.

Description

This entry represents the N-terminal WAHD domain (N-terminal WASH homology regions) of the WASH1 protein, which is a component of the WASH complex that is present at the surface of endosomes and activates the Arp2/3-mediated F-actin polymerisation [PMID: 19922875]. This domain covers the conserved WHD1/EVH1 and WHD2 domains. WASH1 interact with FAM21 via its WHD1 domain and binds to tubulin through its WHD2 domain [PMID: 19922874].

The WASH complex consists of several subunits: F-actin-capping protein subunit alpha (CAPZA1, CAPZA2 or CAPZA3), F-actin-capping protein subunit beta (CAPZB), WASH (WASH1, WASH2P, WASH3P, WASH4P, WASH5P or WASH6P), FAM21 (FAM21A, FAM21B or FAM21C), KIAA1033, KIAA0196 (strumpellin) and CCDC53.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam