Domain

Early growth response protein (IPR021849)

Short name: EGR

Overlapping homologous superfamilies

None.

Domain relationships

None.

Description

Proteins containing this domain include early growth response protein 1/2/3 (EGR1/2/3). EGR1 is a transcriptional regulator that binds specifically to 9-bp target sequences containing two CpG sites that can potentially be methylated at four cytosine bases [PMID: 25999311]. EGR2, also known as Krox20, is an E3 ligase that sumoylates its Nab coregulators [PMID: 21836637].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam