Proteasome activator complex subunit 4 C-terminal domain (IPR021843)

Short name: PSME4_C

Overlapping homologous superfamilies


Domain relationships



This domain is typically between 142 to 163 amino acids in length is found at the C terminus of activator complex subunit 4 (gene name PSME4, PA2000 or BLM10), a component of the 19S cap complex of the eukaryotic 26S proteasome. The tertiary structure of BLM10 from Saccharomyces cerevisiae has been solved, showing that the C terminus is important for helping to form the BLM10 cap that covers the entry pore of the proteasome, restricting access for potential substrates. The C-terminal residues bind in the pocket between proteasome subunits alpha5 and alpha6, in a similar site to where the C-termini of the ATPases of the 19S proteasomal cap also bind [PMID: 20227375].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.