Signal-induced proliferation-associated 1-like protein, C-terminal (IPR021818)

Short name: SIPA1L_C

Domain relationships



This domain is found in C-terminal of the signal-induced proliferation-associated 1-like (SIPA1L) proteins, including SIPA1L 1-3 from humans. SIPA1Ls shares protein sequence similarity with signal-induced proliferation-associated protein 1 (SIPA1), which is a GTPase activator for the nuclear Ras-related regulatory proteins Rap1 and Rap2 [PMID: 9346962, PMID: 15310461]. In rats SIPA1L1 (also known as SPAR) has been identified as a Rap-specific GTPase-activating protein [PMID: 11502259].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.