Domain

Dedicator of cytokinesis C/D, N-terminal (IPR021816)

Short name: DOCK_C/D_N

Domain relationships

None.

Description

DOCK family members are evolutionarily conserved guanine nucleotide exchange factors (GEFs) for Rho-family GTPases [PMID: 12432077]. DOCK proteins are required during several cellular processes, such as cell motility and phagocytosis. The N-terminal SH3 domain of the DOCK proteins functions as an inhibitor of GEF, which can be relieved upon its binding to the ELMO1-3 adaptor proteins, after their binding to active RhoG at the plasma membrane [PMID: 25022758, PMID: 15723800]. DOCK family proteins are categorised into four subfamilies based on their sequence homology: DOCK-A subfamily (DOCK1/180, 2, 5), DOCK-B subfamily (DOCK3,4), DOCK-C subfamily (DOCK 6, 7, 8), DOCK-D subfamily (DOCK 9, 10, 11) [PMID: 12432077].

This entry represents the N-terminal domain of the DOCK-C subfamily (DOCK 6, 7, 8), DOCK-D subfamily (DOCK 9, 10, 11).

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam