Nuclear/hormone receptor activator site AF-1 (IPR021780)

Short name: Nuc_recep-AF1

Overlapping homologous superfamilies


Domain relationships



Nuclear receptors (NRs) are a family of ligand-inducible transcription factors, and, like other transcription factors, they contain a distinct DNA binding domain that allows for target gene recognition and several activation domains that possess the ability to activate transcription [PMID: 12893880]. One of these activation domains is at the N-terminal, although there are two distinct motifs within this domain, between residues 20-36 and between 74 and the end of this domain, which are the binding regions. One of the co-activators is TIF1beta, which appears to bind at the first motif [PMID: 19321449].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.