Histone-lysine N-methyltransferase EZH1/EZH2 (IPR021654)

Short name: EZH1/EZH2

Family relationships


The Polycomb Repressive Complex 2 (PRC2) is a chromatin modifying complex that consists of three core components: EED, SUZ12 and one of the two histone H3K27 methyltransferases, EZH1 or EZH2 [PMID: 24951427]. The PRC2 complex catalyses di- and trimethylation of histone H3 lysine 27 (H3K37me2/3), which has a repressive role. Even though Ezh1 and Ezh2 form similar PRC2 complexes, they exhibit contrasting repressive roles. In terms of their expression in mice, EZH1 is more abundant in nonproliferative adult organs, while EZH2 expression is tightly associated with proliferation [PMID: 19026781].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0018024 histone-lysine N-methyltransferase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.