Family

Lamina-associated polypeptide 2 alpha (IPR021623)

Short name: LAP2alpha

Family relationships

None.

Description

LAPs are components of the nuclear lamina which supports the nuclear envelope.LAP2alpha is a non-membrane-associated member of the LAP family which is unique. This family of proteins is the C-terminal domain of LAP2alpha which consists of residues 459-693 and constitutes a dimeric structure with an antiparallel coiled coil. LAP2alpha is involved in cell-cycle regulation and chromatin organisation and preferentially binds to lamin A/C [PMID: 17562312].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam