Afadin/alpha-actinin-binding (IPR021622)

Short name: Afadin/alpha-actinin-bd

Overlapping homologous superfamilies


Family relationships



This family is found in mammals where it is localised at cell-cell adherens junctions [PMID: 12446711], and in Sch. pombe and other fungi where it anchors spindle-pole bodies to spindle microtubules [PMID: 17486116]. It is a coiled-coil structure, and in pombe, it is required for anchoring the minus end of spindle microtubules to the centrosome equivalent, the spindle-pole body. The name ADIP derives from the family being composed of Afadin- and alpha -Actinin-Binding Proteins Localised at Cell-Cell Adherens Junctions.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.