Family

Transcription activator LAG-3 (IPR021587)

Short name: Transcription_activator_LAG-3

Overlapping homologous superfamilies

None.

Family relationships

None.

Description

The C.elegans Notch pathway, involved in the control of growth, differentiation and patterning in animal development, relies on either of the receptors GLP-1 or LIN-12 [PMID: 10830967]. Both these receptors promote signalling by the recruitment of LAG-3 to target promoters, where it then acts as a transcriptional activator. LAG-3 works as a ternary complex together with the DNA binding protein, LAG-1 [PMID: 10830967].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam