Hypoxia-inducible factor, alpha subunit (IPR021537)

Short name: HIF_alpha_subunit

Overlapping homologous superfamilies


Family relationships


Hypoxia-inducible factors (HIFs) are transcription factors that respond to changes in available oxygen in the cellular environment. Specifically, they respond to decreases in oxygen, mediating the effects of hypoxia [PMID: 18410568]. HIFs are heterodimers, composed of an alpha and a beta subunit. At least 3 different alpha subunits are known to exist, termed HIF-1, -2 and -3 alpha. Beta subunits, meanwhile, are constitutively-expressed aryl hydrocarbon receptor nuclear translocators (ARNTs).

In addition to their role in hypoxia, HIFs have been shown to be involved in a range of processes, including angiogenesis, metal transport, mitochondrial function and cell growth [PMID: 19756382].

This entry represents HIF alpha subunits.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.