Domain

DNA ligase IV domain (IPR021536)

Short name: DNA_ligase_IV_dom

Domain relationships

None.

Description

This entry represents the DNA ligase IV (Lig4) sequences between the two BRCA1 C-terminal (BRCT) domains. Lig4 along with Xrcc4 functions in DNA non-homologous end joining. This process is required to mend double-strand breaks. Upon ligase binding to an Xrcc4 dimer, the helical tails unwind leading to a flat interaction surface [PMID: 11702069].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0003910 DNA ligase (ATP) activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam