Mediator complex, subunit Med25, von Willebrand factor type A (IPR021419)

Short name: Mediator_Med25_VWA

Overlapping homologous superfamilies


Family relationships



The overall function of the full-length Med25 is efficiently to coordinate the transcriptional activation of RAR/RXR (retinoic acid receptor/retinoic X receptor) in higher eukaryotic cells. Human Med25 consists of several domains with different binding properties, the N-terminal, VWA domain which is this one, an SD2 domain from residues 229-381, a PTOV(B) or ACID domain from 395-545, an SD2 domain from residues 564-645 and a C-terminal NR box-containing domain (646-650) from 646-747. This VWA or von Willebrand factor type A domain when bound to RAR and the histone acetyltransferase CBP is responsible for recruiting Med1 to the rest of the Mediator complex [PMID: 17641689].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.