Mediator complex, subunit Med25, NR box (IPR021406)

Short name: Mediator_Med25_NR-box

Overlapping homologous superfamilies


Domain relationships



The overall function of the full-length Med25 is efficiently to coordinate the transcriptional activation of RAR/RXR (retinoic acid receptor/retinoic X receptor) in higher eukaryotic cells. Human Med25 consists of several domains with different binding properties, the N-terminal, VWA, domain, an SD1 - synapsin 1 - domain from residues 229-381, a PTOV(B) or ACID domain from 395-545, an SD2 domain from residues 564-645 and this C-terminal NR box-containing domain (646-650) from C69-747. The NR box of MED25 is critical for its recruitment to the promoter, probably through an interaction with pre bound RAR [PMID: 17641689].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.