Family

Adenovirus L4-33K/L4-22K (IPR021304)

Short name: Adeno_L4-33K/L4-22K

Overlapping homologous superfamilies

None.

Family relationships

None.

Description

Adenoviruses express up to 20 distinct mRNAs from five major late transcription unit (MLTU) regions, L1 to L5. The L4 region expresses L4-33K and a related protein, L4-22K [PMID: 19176628].

L4-22K and L4-33K have complementary but not redundant functions that provide the normal pattern of mRNA production during the late phase of infection [PMID: 19176628]. L4-33K is an alternative RNA splicing factor that upregulates several MLTU splice acceptor sites as the late phase progresses [PMID: 19176628, PMID: 17028184]. L4-22K plays a role in genome packaging via its binding, in association with IVa2, to the A2 sequence within the packaging signal [PMID: 16809303]. Additionally, L4-22K plays an important role in the temporal switch from the early to late phase of infection by regulating both early and late gene expression [PMID: 2363740].

GO terms

Biological Process

GO:0019073 viral DNA genome packaging

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam