Mitochondrial Rho GTPase (IPR021181)

Short name: Mt_Rho_GTPase

Family relationships


Mitochondrial Rho GTPase (also known as Miro-1 and Miro-2, for mitochondrial Rho) is involved in mitochondrial trafficking, most probably in the control of anterograde transport of mitochondria and their subcellular distribution [PMID: 12482879]. They have tandem GTP-binding domains separated by a linker region containing putative calcium-binding EF hand motifs. There appears to be a role for Rho-like GTPases in mitochondrial homeostasis and apoptosis [PMID: 12482879]. The Miro GTPases also have a C-terminal transmembrane domain, which confers targeting to the mitochondria. The protein interacts with the kinesin-binding proteins TRAK1/OIP106 and TRAK2/GRIF1, forming a link between mitochondria and the trafficking apparatus of the microtubules [PMID: 16630562].

Miro is conserved from yeast to humans. In yeasts and plants, Miro plays roles in mitochondrial homeostasis, but the ability to build a complex that regulates its association to kinesin for microtubule-dependent transport probably arose in metazoans [PMID: 21131095].

GO terms

Biological Process

GO:0007005 mitochondrion organization

Molecular Function

GO:0005525 GTP binding
GO:0003924 GTPase activity
GO:0005509 calcium ion binding

Cellular Component

GO:0031307 integral component of mitochondrial outer membrane
GO:0005739 mitochondrion

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.