Mitochondrial Rho GTPase (IPR021181)

Short name: Miro

Overlapping homologous superfamilies


Family relationships


Mitochondrial Rho (Miro) proteins are aberrant members of the small GTPase superfamily found in most eukaryotes. Miro contains a transmembrane region located at the C terminus anchors the protein to the outer membrane of mitochondria, the GTPase domains and EF-hands located in the cytoplasm. Miro and its cytoplasmic binding partner Milton/TRAK link mitochondria to kinesin and dynein molecular motors in various cell types [PMID: 27064409]. Mammals have two Miro orthologs , Miro1 and Miro2. They mediate mitochondrial trafficking in neurons by linking mitochondria to kinesin and dynein motor proteins for their transport in axons and dendrites [PMID: 24711517, PMID: 27386195]. Yeasts have one Miro homologue, known as Gem1, which is part of the ERMES complex that links the ER to mitochondria [PMID: 21825164]. Interestingly, ERMES is absent in metazoa [PMID: 28122638].

GO terms

Biological Process

GO:0007005 mitochondrion organization

Molecular Function

GO:0005525 GTP binding
GO:0003924 GTPase activity
GO:0005509 calcium ion binding

Cellular Component

GO:0031307 integral component of mitochondrial outer membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.