Pathways & interactions
Core histone macro-H2A (IPR021171)
Short name: Core_histone_macro-H2A
Overlapping homologous superfamilies
- Histone H2A (IPR002119)
- Core histone macro-H2A (IPR021171)
This group represents a core histone macro-H2A.
MacroH2A is a variant of the major-type core histone H2A which contains an N-terminal H2A domain and a C-terminal nonhistone macro domain. Histone macroH2A is enriched on the inactive X chromosome of mammalian female cells [PMID: 11433014]. It does not bind poly ADP-ribose, but does bind the monomeric SirT1 metabolite O-acetyl-ADP-ribose (OAADPR) with high affinity through its macro domain [PMID: 15965484]. In addition, the macro domain of macroH2A associates with histone deacetylases and affects the acetylation status of nucleosomes. MacroH2A-containing nucleosomes are repressive toward transcription [PMID: 16107708].
- PIRSF037942 (Core_histone_macro-H2A)