Core histone macro-H2A (IPR021171)

Short name: Core_histone_macro-H2A

Overlapping homologous superfamilies


Family relationships

  • Histone H2A (IPR002119)
    • Core histone macro-H2A (IPR021171)


This group represents a core histone macro-H2A.

MacroH2A is a variant of the major-type core histone H2A which contains an N-terminal H2A domain and a C-terminal nonhistone macro domain. Histone macroH2A is enriched on the inactive X chromosome of mammalian female cells [PMID: 11433014]. It does not bind poly ADP-ribose, but does bind the monomeric SirT1 metabolite O-acetyl-ADP-ribose (OAADPR) with high affinity through its macro domain [PMID: 15965484]. In addition, the macro domain of macroH2A associates with histone deacetylases and affects the acetylation status of nucleosomes. MacroH2A-containing nucleosomes are repressive toward transcription [PMID: 16107708].

GO terms

Biological Process

GO:0006334 nucleosome assembly

Molecular Function

GO:0003677 DNA binding

Cellular Component

GO:0000786 nucleosome

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.