Pathways & interactions
Glycerate/sugar phosphate transporter, conserved site (IPR021159)
Short name: Sugar-P_transporter_CS
Proteins in this group are involved in the transport system that mediates the uptake of a number of sugar phosphates as well as the regulatory components that are responsible for induction of this transport system by external glucose 6-phosphate. In Escherichia coli its role in transmembrane signalling may involve sugar-phosphate-binding sites and transmembrane orientations similar to those of the transport protein [PMID: 3301805]. The following proteins in this entry, involved in the uptake of phosphorylated metabolites, are evolutionary related [PMID: 3042749, PMID: 8438231]:
- E. coli, Bacillus subtilis and Haemophilus influenzae glycerol-3- phosphate transporter (gene glpT).
- Salmonella typhimurium phosphoglycerate transporter (gene pgtP).
- E. coli and S. typhimurium hexose-6-phosphate transporter (gene uhpT).
- E. coli and S. typhimurium protein uhpC. UhpC is necessary for the expression of uhpT and seems to act jointly with the uhpB sensor/kinase protein.
- Human glucose 6-phosphate translocase [PMID: 9428641].
These proteins of about 50 kDa apparently contain 12 transmembrane regions.
This entry represents a conserved region in the central section of these transporters.
- PS00942 (GLPT)