KduI/IolB isomerase (IPR021120)

Short name: KduI/IolB_isomerase

Overlapping homologous superfamilies

Family relationships


The KduI/IolB family of enzymes includes 5-keto 4-deoxyuronate isomerase (KduI) and 5-deoxy-glucuronate isomerase (IolB).

KduI is involved in pectin degradation by free-living soil bacteria that use pectin as a carbon source, breaking it down to 2-keto-3-deoxygluconate, which can ultimately be converted to pyruvate. KduI catalyses the fourth step in pectin degradation, namely the interconversion of 5-keto-4-deoxyuronate and 2,5-diketo-3-dexoygluconate [PMID: 1766386]. KduI has a TIM-barrel fold [PMID: 16152643].

IolB is one of several bacterial proteins encoded by the inositol operon (iolABCDEFGHIJ) in Bacillus subtilis that are involved in myo-inositol catabolism. The enzyme is responsible for isomerization of 5-deoxy-D-glucuronic acid by IolB to produce 2-deoxy-5-keto-D-gluconic acid [PMID: 18310071]. IolBs possess a cupin-like structure.

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.