Family

Calcitonin (IPR021118)

Short name: Calcitonin

Family relationships

Description

The calcitonin (CT) gene is alternatively expressed in a tissue-specific manner, producing either the calcium regulatory hormone CT in the thyroid, or the neuropeptide calcitonin gene related peptide (CGRP) in the brain [PMID: 2985435]. In medullary carcinoma of the thyroid, both peptides are produced [PMID: 2985435]. The calcitonin regulatory hormone is a peptide of 32 residues that causes a rapid but short-lived drop in calcium and phosphate levels in the blood by promoting the incorporation of these ions in the bones [PMID: 3060108]. The structure of Oncorhynchus keta (Chum salmon) calcitonin has been studied by 2D NMR in SDS micelles [PMID: 1931969]. The main conformational feature of the hormone is an alpha-helix from residues 6-22, which includes an amphipathic segment. Two cysteine residues (at positions 1 and 7) form an N-terminal loop, and a C-terminal decapeptide forms a loop that folds back towards the helix [PMID: 1931969].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0005179 hormone activity

Cellular Component

GO:0005576 extracellular region

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PRINTS