Domain

KfrA, N-terminal DNA-binding domain (IPR021104)

Short name: KfrA_DNA-bd_N

Overlapping homologous superfamilies

None.

Domain relationships

None.

Description

The KfrA family of proteins are encoded on plasmids, generally in or near gene clusters involved in stable inheritance functions. These proteins are thought to form an all-helical structure, consisting of an N-terminal helix-turn-helix DNA binding domain and an extended coiled-coil tail. The best-characterised KfrA protein, encoded on the broad host-range Plasmid RK2, is a site-specific DNA-binding protein whose operator overlaps its own promoter. The DNA-binding domain is essential for function, while the coiled-coil domain is probably responsible for formation of multimers, and may provide an example of a bridge to host structures required for plasmid partitioning [PMID: 1602476].

This entry represents the N-terminal DNA-binding domain.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam