Protein GAPT (IPR021082)

Short name: Protein_GAPT

Overlapping homologous superfamilies


Family relationships



Protein GAPT (also known as Growth-factor Receptor-Bound protein 2 (GRB2)-binding adaptor protein, transmembrane) belongs to a class of transmembrane (TM) adaptor proteins that couple antigen receptor engagement to downstream signalling cascades in lymphocytes [PMID: 18559951]. Expressed in B cells and myeloid cells, GAPT negatively regulates B-cell proliferation following stimulation through the B-cell receptor; it may also play an important role in the proper maintenance of marginal zone B-cells [PMID: 18559951].

GAPT has an extracellular domain, a TM domain, and a cytoplasmic tail with multiple GRB2-binding motifs; it constitutively associates with GRB2 SH3 domains via a proline-rich region [PMID: 18559951]. Its cytosolic domain contains 7 tyrosine residues (4 of them within GRB2-binding motifs), and 2 cysteines in the juxta-membrane region, which may be palmitoylated [PMID: 18559951].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0016021 integral component of membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.