Domain

MKI67 FHA domain-interacting nucleolar phosphoprotein, FHA Ki67 binding (IPR021043)

Short name: hNIFK_FHA_Ki67_binding

Domain relationships

None.

Description

This entry represents eukaryotic proteins that contain a domain of approximately 40 amino acids in length. These proteins are found in association with PF00076. There are two conserved sequence motifs: TPVCTP and LERRKS. This domain is found on the human nucleolar protein hNIFK. It binds to the fork-head-associated domain of human Ki67. High-affinity binding requires sequential phosphorylation by two kinases, CDK1 and GSK3, yielding pThr238, pThr234 and pSer230. This interaction is involved in cell cycle regulation [PMID: 16244663].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam