Domain

LRRC8, pannexin-like TM region (IPR021040)

Short name: LRRC8_Pannexin-like

Domain relationships

None.

Description

This entry represents the four transmembrane domains of metazoan leucine-rich-repeat-containing 8 proteins. These four TMs associate into hexamers resulting in homo- or heteromeric channels that connect the cytosol to the extracellular space [PMID: 22532330].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam