Family

HDA1 complex subunit 2/3 (IPR021006)

Short name: Hda2/3

Family relationships

Description

This entry contains the class II histone deacetylase complex subunits Hda2 and Hda3 from fungi.

Hda2/3 associate with Hda1 to generate the activity of the Hda1 histone deacetylase complex. Hda1 interacts with itself and with the Hda2-Hda3 subcomplex to form a probable tetramer and these interactions are necessary for catalytic activity. The Hda1 histone deacetylase complex is responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Hda2 and Hda3 have a conserved coiled-coil domain towards their C terminus [PMID: 11287668].

GO terms

Biological Process

GO:0016575 histone deacetylation

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0070823 HDA1 complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam