Centromere protein Cenp-K (IPR020993)

Short name: Centromere_CenpK

Overlapping homologous superfamilies


Family relationships



Cenp-K is one of seven new Cenp-A-nucleosome distal (CAD) centromere components (the others being Cenp-L, Cenp-O, Cenp-P, Cenp-Q, Cenp-R and Cenp-S) that are identified as assembling on the Cenp-A nucleosome associated complex, NAC [PMID: 16622419]. The Cenp-A NAC is essential, as disruption of the complex causes errors of chromosome alignment and segregation that preclude cell survival despite continued centromere-derived mitotic checkpoint signalling. Cenp-K is centromere-associated through its interaction with one or more components of the Cenp-A NAC. It may be involved in incorporation of newly synthesized Cenp-A into centromeres via its interaction with the Cenp-A-NAC complex [PMID: 18045986].

The homologue in Schizosaccharomyces pombe is known as inner kinetochore subunit sim4 [PMID: 12719471, PMID: 18007590].

GO terms

Biological Process

GO:0051382 kinetochore assembly

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0005634 nucleus

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.