Bacteriophage T4, GpT, holin (IPR020982)

Short name: Phage_T4_GpT_holin

Overlapping homologous superfamilies


Family relationships



One mechanism by which bacteriophages effect host lysis begins with the accumulation of a holin in the host membrane and an endolysin in the host cytoplasm during late gene expression. At an allele-specific time, the holin disrupts the membrane, thus allowing the endolysin to enter the periplasm and degrade the cell wall peptidoglycan. This entry represents a specific holin, known as T, which has an unusual C-terminal periplasmic domain thought to be involved in the transduction of environmental information for the real-time control of lysis timing [PMID: 16166524].

GO terms

Biological Process

GO:0044659 cytolysis by virus of host cell

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.