Monopolin complex, subunit Csm1/Pcs1 (IPR020981)

Short name: Monopolin_cplx_su-Csm1/Pcs1

Overlapping homologous superfamilies

Domain relationships



Saccharomyces cerevisiae Csm1 is part of the monopolin complex. Csm1 forms a complex with Mde4 and promotes monoorientation during meiosis [PMID: 15023545]. It plays a mitotic role in DNA replication [PMID: 15023545] and is required for condensin recruitment to the replication fork barrier site and rDNA repeat segregation [PMID: 19362534]. This entry also contains the Schizosaccharomyces pombe homologue to Csm1, Pcs1. Pcs1 forms a complex with Mde4 and acts in the central kinetochore domain to clamp microtubule binding sites together[PMID: 17627824]. The two complexes (Csm1/Lrs4 and Pcs1/Mde4) contribute to the prevention of merotelic attachment [PMID: 17627824].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0005515 protein binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.