Suppressor of fused-like domain (IPR020941)

Short name: SUFU-like_domain

Overlapping homologous superfamilies

Domain relationships



Sufu, encoding the human ortholog of Drosophila suppressor of fused, appears to have a conserved role in the repression of Hedgehog signalling. It is a repressor of the Gli and Ci transcription factors of the Hedgehog signalling cascade [PMID: 12150819], and functions by binding these proteins and preventing their translocation to the nucleus. Sufu has been found to be a tumour-suppressor gene that predisposes individuals to medulloblastoma by modulating the SHH signalling pathway [PMID: 12068298]. Homologues of Sufu have been found in bacteria, though their function is not currently known.

This entry represents a domain found in Sufu and its homologues. It is also found in other proteins that are functionally uncharacterised. In eukaryotic Sufu, an additional domain (PF12470) is found at the C terminus of the protein. This domain binds to the C-terminal domain of the Gli/Ci transcription factors, inhibiting their activity [PMID: 15367681].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.