Pacifastin, arthropoda (IPR020862)

Short name: Pacifastin_art


This entry represents pacifastin composed of proteinase inhibitors confined to arthropods:

  • Pacifastacus leniusculus (Signal crayfish) pacifastin light chain.
  • Locusta migratoria (Migratory locust) LMPI-1 to -3.
  • Schistocerca gregaria (Desert locust) SGPI-1 to -5.
  • Aedes aegypti (Yellowfever mosquito) AAPP-1.
  • Anopheles gambiae (African malaria mosquito) AGPP-1.

These proteinase inhibitors belong to family I19 and share a pacifastin domain of ~35 residues, which contains a characteristic pattern of six conserved cysteine residues (C-x(9,12)-C-N-x-C-x-C-x(2,3)-G-x(3,6)-C-T-x(3)- C). The pacifastin domain consists of a twisted beta-sheet composed of three antiparallel strands and stabilised by an identical pattern (C1-C4, C2-C6, C3-C5) of disulphide bridges [PMID: 9192625, PMID: 11495915, PMID: 11997226, PMID: 11856311, PMID: 15631618].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE profiles