Domain

MIRO domain (IPR020860)

Short name: MIRO_dom

Domain relationships

Description

Mitochondrial Rho proteins (Miro-1, Q8IXI2 and Miro-2, Q8IXI1) are atypical Rho GTPases. They have a unique domain organisation, with tandem GTP-binding domains and two EF hand domains (IPR002048), that may bind calcium. They are also larger than classical small GTPases. It has been proposed that they are involved in mitochondrial homeostasis and apoptosis [PMID: 12482879].

This entry represents the tandemly repeated GTPase domain from these proteins.

GO terms

Biological Process

GO:0007264 small GTPase mediated signal transduction

Molecular Function

GO:0005525 GTP binding
GO:0003924 GTPase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE profiles