Peptide chain release factor 2, bacterial (IPR020853)

Short name: RF2_bac

Family relationships


Peptide chain release factors (RFs) are required for the termination of protein biosynthesis [PMID: 8821264]. At present two classes of RFs can be distinguished. Class I RFs bind to ribosomes that have encountered a stop codon at their decoding site and induce release of the nascent polypeptide. Class II RFs are GTP-binding proteins that interact with class I RFs and enhance class I RF activity. In prokaryotes there are two class I RFs that act in a codon specific manner [PMID: 2215213]: RF-1 (gene prfA) mediates UAA and UAG-dependent termination while RF-2 (gene prfB), which is represented by this entry, mediates UAA and UGA-dependent termination. RF-1 and RF-2 are structurally and evolutionary related proteins which have been shown [PMID: 1408743] to be part of a larger family.

This family consists of RF-2 from bacteria.

GO terms

Biological Process

GO:0006415 translational termination

Molecular Function

GO:0016149 translation release factor activity, codon specific

Cellular Component

GO:0005737 cytoplasm

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.