Domain

DBINO domain (IPR020838)

Short name: DBINO

Domain relationships

None.

Description

Proteins belonging to the SNF2 family of DNA dependent ATPases are important members of the chromatin remodelling complexes that are implicated in epigenetic control of gene expression. Members of the SNF2 family of proteins have been identified in organisms ranging from Escherichia coli to Homo sapiens (Human). All of them contain the conserved SNF2 domain, which is defined by the existence of seven motifs (I, Ia, and II-VI) with sequences similarity to those motifs found in DNA and RNA helicases (see PDOC51192). SNF2-like family members can be further subdivided into several subfamilies according to the presence of protein motifs outside of the ATPase region. The DBINO (DNA binding domain of INO80) domain is characteristic of the INO80 subfamily and is predicted to have DNA-binding function. The DBINO domain is a 126 amino acid long peptide located near the N terminus, approximately 100 residues upstream of the SNF2 helicase domain. The presence of this domain in all the INO80 subfamily proteins from yeast to humans suggests its conserved function in evolution [PMID: 15207721, PMID: 16298340].

The most significant feature of DBINO domain is the occurrence of the positive amino acids arginine and lysine in tandem (RK/KR), in multiple positions, which are likely to bind DNA [PMID: 15207721].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0016817 hydrolase activity, acting on acid anhydrides

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE profiles
Pfam