Binding Site

Lipoxygenase, iron binding site (IPR020833)

Short name: LipOase_Fe_BS

Description

Lipoxygenases (EC:1.13.11.-) are a class of iron-containing dioxygenases which catalyses the hydroperoxidation of lipids, containing a cis,cis-1,4-pentadiene structure. They are common in plants where they may be involved in a number of diverse aspects of plant physiology including growth and development, pest resistance, and senescence or responses to wounding. In mammals a number of lipoxygenases isozymes are involved in the metabolism of prostaglandins and leukotrienes [PMID: 3017195]. Sequence data is available for the following lipoxygenases:

  • Plant lipoxygenases (EC:1.13.11.12). Plants express a variety of cytosolic isozymes as well as what seems to be a chloroplast isozyme [PMID: 7508918].
  • Mammalian arachidonate 5-lipoxygenase (EC:1.13.11.34).
  • Mammalian arachidonate 12-lipoxygenase (EC:1.13.11.31).
  • Mammalian erythroid cell-specific 15-lipoxygenase (EC:1.13.11.33).

The iron atom in lipoxygenases is bound by four ligands, three of which are histidine residues [PMID: 8502991]. Six histidines are conserved in all lipoxygenase sequences, five of them are found clustered in a stretch of 40 amino acids. This region contains two of the three iron-ligands; the other histidines have been shown [PMID: 1567851] to be important for the activity of lipoxygenases.

This entry represents a motif that contains the iron-binding sites.

GO terms

Biological Process

GO:0055114 oxidation-reduction process

Molecular Function

GO:0046872 metal ion binding
GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE patterns