Conserved Site

Fibrillarin, conserved site (IPR020813)

Short name: Fibrillarin_CS


Fibrillarin is a component of a nucleolar small nuclear ribonucleoprotein (SnRNP), functioning in vivo in ribosomal RNA processing [PMID: 2026646, PMID: 8493104]. It is associated with U3, U8 and U13 small nuclear RNAs in mammals [PMID: 2026646] and is similar to the yeast NOP1 protein [PMID: 2686980]. Fibrillarin has a well conserved sequence of around 320 amino acids, and contains 3 domains, an N-terminal Gly/Arg-rich region; a central domain resembling other RNA-binding proteins and containing an RNP-2-like consensus sequence; and a C-terminal alpha-helical domain. An evolutionarily related pre-rRNA processing protein, which lacks the Gly/Arg-rich domain, has been found in various archaebacteria.

The signature pattern for this entry encompasses the RNP-2 like octapeptide sequence.

GO terms

Biological Process

GO:0006364 rRNA processing

Molecular Function

GO:0003723 RNA binding
GO:0008168 methyltransferase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE patterns