Polyketide synthase, methyltransferase domain (IPR020803)

Short name: PKS_MeTfrase

Overlapping homologous superfamilies

Domain relationships



Methyl transfer from the ubiquitous donor S-adenosyl-L-methionine (SAM) to either nitrogen, oxygen or carbon atoms is frequently employed in diverse organisms ranging from bacteria to plants and mammals. The reaction is catalyzed by methyltransferases (Mtases) and modifies DNA, RNA, proteins and small molecules, such as catechol for regulatory purposes. The various aspects of the role of DNA methylation in prokaryotic restriction-modification systems and in a number of cellular processes in eukaryotes including gene regulation and differentiation is well documented.

This entry represents a methyltransferase domain found in polyketide synthases.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.