Binding Site

RNA polymerases, subunit N, zinc binding site (IPR020789)

Short name: RNA_pol_suN_Zn-BS


In eukaryotes, there are three different forms of DNA-dependent RNA polymerases (EC: transcribing different sets of genes. Each class of RNA polymerase is an assemblage of ten to twelve different polypeptides. In archaebacteria, there is generally a single form of RNA polymerase which also consists of an oligomeric assemblage of 10 to 13 polypeptides. Archaebacterial subunit N (gene rpoN) [PMID: 7597027] is a small protein of about 8 kDa, it is evolutionary related [PMID: 8045907] to a 8.3 kDa component shared by all three forms of eukaryotic RNA polymerases (gene RPB10 in yeast and POLR2J in mammals) as well as to African swine fever virus (ASFV) protein CP80R [PMID: 11831707].

This signature spans the conserved region, which is located at the N-terminal extremity of these polymerase subunits; this region contains two cysteines that binds a zinc ion [PMID: 10841539].

GO terms

Biological Process

GO:0006351 transcription, DNA-templated

Molecular Function

GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0008270 zinc ion binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE patterns